An innovative antibacterial peptide from snake venom has been created by researchers at the Indian Institute of Technology (IIT) Jodhpur, and it may help wounds heal more rapidly. The prevention of wound infection following surgery has also been demonstrated to be successful using the murine model peptide. The primary objective of this design technique, according to Dr. Surjit Ghosh, Professor in the Department of Bioscience and Bioengineering and Department of Smart Healthcare, IIT Jodhpur, was to lower the danger of snake venom without losing its antibacterial characteristics. This was accomplished by fully removing the poisonous portion of the snake venom.
Furthermore, a short helical peptide was added at the N-terminus to help our newly developed therapy penetrate the bacterial cell more easily. Scientists throughout the world are working to find answers to the threat posed by bacterial drug resistance. Different hydrophobicity and charge configurations are present in the majority of naturally occurring antimicrobial peptides, which contribute to their potent bacterial killing abilities. Despite their promise, their application as therapeutic compounds for humans is generally restricted, said Dr. Ghosh.
This study from IIT Jodhpur gives remedies to two significant issues. First, the peptide’s capacity for membrane lysis. The non-specific nature reduces the likelihood that bacteria may develop a resistance to it. Second, the peptide can be used alone or in conjunction with other medications and peptides as a disinfectant and ointment for wound healing. It can be administered systemically orally, via injection, or as an aerosolized formulation for medicinal purposes.
Researchers Dr. Surjit Ghosh, Dr. Samya Sen, Ramkamal Samat, Dr. Moumita Jash, Satyajit Ghosh, Rajshekhar Roy, Nabanita Mukherjee, Surojit Ghosh, and Dr. Jayita Sarkar collaborated on a study that was published in the Journal of Medicinal Chemistry. This work was first electronically submitted for a patent in India. The study’s funding came from the Sustainable Entrepreneurship and Enterprise Development (SEED) fund of IIT Jodhpur and the Science and Engineering Research Board (SERB) of India.